The CDC recently added a category of COVID variants called substitutions of therapeutic concern. These substitutions are present in several different variants and can make some antibody treatments less effective. There were more than 700 cases identified in two strains identified as E484K and L452R. The CDC now has three categories for COVID-19 variants: those of interest, of concern and of high consequence. None of the high consequence strains have been identified in Connecticut through genomic testing. The ones of concern include the ones first detected in the U-K, South Africa, Brazil and two in California. The ones of interest are two first identified in New York, one in Brazil and one in Africa and Europe.